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PERNICIOUS ANEMIA - vitamin B 12 deficiency

CAUSE : when there is defect in the gastric secretory function responsible for vitamin B 12 absorption

SIGNS AND SYMPTOMS:
1. physical weakness

  • pallor
  • dyspnea- difficulty of breathing
  • orthopnea- ability to breath only when in upright position like sitting or standing
  • palpitation
  • edema of the legs- (edema- presence of excess fluid )
2. Gastrointestinal Symptom:
  • sore in the mouth with smooth red beefy tongue (glossitis)
  • loss of appetite
  • indigestion
  • abdominal pain
  • recurring diarrhea and constipation
3. neurologic symptoms if untreated:
  • tingling
  • numbness or burning pains
  • loss of position sense leading to disturbance of gait
4.psychiatric symptoms:
  • depression
  • paranoea
  • delirium
  • anorexia
  • weight loss

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