nurse's notes

APLASTIC ANEMIA- disorder characterized by hyperplasia or aplasia (failure) resulting of bone marrow depression or destruction

CAUSES:

• drug or chemical or the result of radiation damaged
• caused by agents produced by marrow aplasia such as benzene derivatives, anti tumor agents
• agents responsible for aplasia such as anti-convulsant, anti microbials, anti thyroids, antidiabetic, anti histamine, analgesics, sedatives, insecticides or heavy metal
• toxic materials such as inorganic arsenic
• viral infections especially hepatitis
  

SIGNS AND SYMPTOMS:
1. abnormal bleeding resulting from thrombocytopenia

• bleeding from gums, nose, gastrointestinal tract and genitourinary tract
• purpura, petechiae, ecchymoses

2. anemia- resulting from depression of hemoglobin

• pallor, weakness
• exertional dyspnea, palpitations

3. infection with high fever- resulting from granulocytopenia

• pharyngitis and oropharyngeal mucositis
• sepsis via gastrointestinal tract or genitourinary tract

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